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Natural Product Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Agrimol B inhibits PDAC growth both in vitro and in vivo . (A) A CCK-8 assay was used to evaluate the pharmacodynamic patterns of 62 natural polyphenols. (B) <t>Polyphenol</t> classification and chemical structure. (C) Viability of PANC-1 cells treated with 62 drugs (10 μmol/l). (D) Chemical structure of Agrimol B. (E) PANC-1, CFPAC-1, and AsPC-1 cell lines were treated with various concentrations of Agrimol B for 24 h. (F) IC50 of Agrimol B in PDAC cells. (G, H) PDAC cells were treated with the indicated concentrations of Agrimol B. Cell proliferation was measured by a colony formation assay. (I) Flow cytometric analysis of PDAC cells treated with different concentrations of Agrimol B for 24 h. (J) Western blot analysis of caspase 9 and cleaved caspase 9 in PDAC cells treated with the indicated concentrations of Agrimol B for 24 h. (K) Tumours from the xenograft model treated with Agrimol B or vehicle. (M, N) Tumour volume and weight in mice in the cohorts treated with Agrimol B or vehicle. (L, O) Immunohistochemical staining of Ki67 in a xenograft model from the vehicle group or the Agrimol B group. Relative immunohistochemical scores were determined by multiplying the range of positively stained cells. Scale bars, 100 μm.
Polyphenol Natural Product Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Agrimol B inhibits PDAC growth both in vitro and in vivo . (A) A CCK-8 assay was used to evaluate the pharmacodynamic patterns of 62 natural polyphenols. (B) <t>Polyphenol</t> classification and chemical structure. (C) Viability of PANC-1 cells treated with 62 drugs (10 μmol/l). (D) Chemical structure of Agrimol B. (E) PANC-1, CFPAC-1, and AsPC-1 cell lines were treated with various concentrations of Agrimol B for 24 h. (F) IC50 of Agrimol B in PDAC cells. (G, H) PDAC cells were treated with the indicated concentrations of Agrimol B. Cell proliferation was measured by a colony formation assay. (I) Flow cytometric analysis of PDAC cells treated with different concentrations of Agrimol B for 24 h. (J) Western blot analysis of caspase 9 and cleaved caspase 9 in PDAC cells treated with the indicated concentrations of Agrimol B for 24 h. (K) Tumours from the xenograft model treated with Agrimol B or vehicle. (M, N) Tumour volume and weight in mice in the cohorts treated with Agrimol B or vehicle. (L, O) Immunohistochemical staining of Ki67 in a xenograft model from the vehicle group or the Agrimol B group. Relative immunohistochemical scores were determined by multiplying the range of positively stained cells. Scale bars, 100 μm.
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targetmol natural compound library  (TargetMol)
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Agrimol B inhibits PDAC growth both in vitro and in vivo . (A) A CCK-8 assay was used to evaluate the pharmacodynamic patterns of 62 natural polyphenols. (B) <t>Polyphenol</t> classification and chemical structure. (C) Viability of PANC-1 cells treated with 62 drugs (10 μmol/l). (D) Chemical structure of Agrimol B. (E) PANC-1, CFPAC-1, and AsPC-1 cell lines were treated with various concentrations of Agrimol B for 24 h. (F) IC50 of Agrimol B in PDAC cells. (G, H) PDAC cells were treated with the indicated concentrations of Agrimol B. Cell proliferation was measured by a colony formation assay. (I) Flow cytometric analysis of PDAC cells treated with different concentrations of Agrimol B for 24 h. (J) Western blot analysis of caspase 9 and cleaved caspase 9 in PDAC cells treated with the indicated concentrations of Agrimol B for 24 h. (K) Tumours from the xenograft model treated with Agrimol B or vehicle. (M, N) Tumour volume and weight in mice in the cohorts treated with Agrimol B or vehicle. (L, O) Immunohistochemical staining of Ki67 in a xenograft model from the vehicle group or the Agrimol B group. Relative immunohistochemical scores were determined by multiplying the range of positively stained cells. Scale bars, 100 μm.
Targetmol Natural Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/targetmol natural compound library/product/TargetMol
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targetmol natural compound library - by Bioz Stars, 2026-06
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targetmol library  (TargetMol)
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TargetMol targetmol library
Agrimol B inhibits PDAC growth both in vitro and in vivo . (A) A CCK-8 assay was used to evaluate the pharmacodynamic patterns of 62 natural polyphenols. (B) <t>Polyphenol</t> classification and chemical structure. (C) Viability of PANC-1 cells treated with 62 drugs (10 μmol/l). (D) Chemical structure of Agrimol B. (E) PANC-1, CFPAC-1, and AsPC-1 cell lines were treated with various concentrations of Agrimol B for 24 h. (F) IC50 of Agrimol B in PDAC cells. (G, H) PDAC cells were treated with the indicated concentrations of Agrimol B. Cell proliferation was measured by a colony formation assay. (I) Flow cytometric analysis of PDAC cells treated with different concentrations of Agrimol B for 24 h. (J) Western blot analysis of caspase 9 and cleaved caspase 9 in PDAC cells treated with the indicated concentrations of Agrimol B for 24 h. (K) Tumours from the xenograft model treated with Agrimol B or vehicle. (M, N) Tumour volume and weight in mice in the cohorts treated with Agrimol B or vehicle. (L, O) Immunohistochemical staining of Ki67 in a xenograft model from the vehicle group or the Agrimol B group. Relative immunohistochemical scores were determined by multiplying the range of positively stained cells. Scale bars, 100 μm.
Targetmol Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Agrimol B inhibits PDAC growth both in vitro and in vivo . (A) A CCK-8 assay was used to evaluate the pharmacodynamic patterns of 62 natural polyphenols. (B) Polyphenol classification and chemical structure. (C) Viability of PANC-1 cells treated with 62 drugs (10 μmol/l). (D) Chemical structure of Agrimol B. (E) PANC-1, CFPAC-1, and AsPC-1 cell lines were treated with various concentrations of Agrimol B for 24 h. (F) IC50 of Agrimol B in PDAC cells. (G, H) PDAC cells were treated with the indicated concentrations of Agrimol B. Cell proliferation was measured by a colony formation assay. (I) Flow cytometric analysis of PDAC cells treated with different concentrations of Agrimol B for 24 h. (J) Western blot analysis of caspase 9 and cleaved caspase 9 in PDAC cells treated with the indicated concentrations of Agrimol B for 24 h. (K) Tumours from the xenograft model treated with Agrimol B or vehicle. (M, N) Tumour volume and weight in mice in the cohorts treated with Agrimol B or vehicle. (L, O) Immunohistochemical staining of Ki67 in a xenograft model from the vehicle group or the Agrimol B group. Relative immunohistochemical scores were determined by multiplying the range of positively stained cells. Scale bars, 100 μm.

Journal: Precision Clinical Medicine

Article Title: Agrimol B inhibits pancreatic ductal adenocarcinoma by induction of lethal mitophagy through decreasing mitochondrial transcription termination factor 3

doi: 10.1093/pcmedi/pbag009

Figure Lengend Snippet: Agrimol B inhibits PDAC growth both in vitro and in vivo . (A) A CCK-8 assay was used to evaluate the pharmacodynamic patterns of 62 natural polyphenols. (B) Polyphenol classification and chemical structure. (C) Viability of PANC-1 cells treated with 62 drugs (10 μmol/l). (D) Chemical structure of Agrimol B. (E) PANC-1, CFPAC-1, and AsPC-1 cell lines were treated with various concentrations of Agrimol B for 24 h. (F) IC50 of Agrimol B in PDAC cells. (G, H) PDAC cells were treated with the indicated concentrations of Agrimol B. Cell proliferation was measured by a colony formation assay. (I) Flow cytometric analysis of PDAC cells treated with different concentrations of Agrimol B for 24 h. (J) Western blot analysis of caspase 9 and cleaved caspase 9 in PDAC cells treated with the indicated concentrations of Agrimol B for 24 h. (K) Tumours from the xenograft model treated with Agrimol B or vehicle. (M, N) Tumour volume and weight in mice in the cohorts treated with Agrimol B or vehicle. (L, O) Immunohistochemical staining of Ki67 in a xenograft model from the vehicle group or the Agrimol B group. Relative immunohistochemical scores were determined by multiplying the range of positively stained cells. Scale bars, 100 μm.

Article Snippet: The polyphenol natural product library (L6100) and Agrimol B (T4S1173) were purchased from TargetMol.

Techniques: In Vitro, In Vivo, CCK-8 Assay, Colony Assay, Western Blot, Immunohistochemical staining, Staining